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  • Starch Intake and Breast Cancer

    ScienceDaily (Dec. 8, 2011) — Researchers have linked increased starch intake to a greater risk for breast cancer recurrence, according to results presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011.

    “The results show that it’s not just overall carbohydrates, but particularly starch,” said Jennifer A. Emond, M.S., a public health doctoral student at the University of California, San Diego. “Women who increased their starch intake over one year were at a much likelier risk for recurring.”

    Researchers conducted a subset analysis of 2,651 women who participated in the Women’s Healthy Eating and Living (WHEL) Dietary Intervention Trial, a plant-based intervention trial that enrolled about 3,088 survivors of breast cancer. WHEL researchers studied breast cancer recurrence and followed the participants for an average of seven years.

    The subset analysis involved an examination of how changes in carbohydrate intake influenced breast cancer recurrence. “The WHEL dietary trial, even though it focused on fruits and vegetables, fiber and fat, didn’t really have a specific carbohydrate goal,” Emond said.

    She and her colleagues obtained carbohydrate intake information from multiple 24-hour dietary recalls at baseline and at one year. In an annual phone interview, participants reported everything they had eaten during the last 24 hours. At baseline, carbohydrate intake was 233 grams per day. Results showed that women whose cancer recurred had a mean increase in carbohydrate intake of 2.3 grams per day during the first year, while women whose cancer did not recur reported a mean decrease of 2.7 grams per day during the first year.

    Starches were particularly important, Emond said. Changes in starch intake accounted for 48 percent of the change in carbohydrate intake. Mean change in starch intake during the first year was -4.1 grams per day among women whose cancer recurred vs. -8.7 grams per day among women whose cancer did not recur.

    When change in starch intake during one year was grouped into quartiles of change, the rate of an additional breast cancer event was 9.7 percent among women who decreased their starch intake the most during one year, compared with an event rate of 14.2 percent among women who increased their starch intake the most during one year.

    The change in starch intake was “independent of dietary changes that happened in the intervention arm,” Emond said. “It is independent of more global changes in diet quality.”

    After stratifying patients by tumor grade, Emond and colleagues found that the increased risk was limited to women with lower-grade tumors.

    These results indicate a need for more research on dietary recommendations that consider limited starch intake among women with breast cancer.

  • Trans Fats Linked to “Brain Shrinkage”

    Diet, Shrinking Brains and “silent strokes”

    guest article by CNN’s Azadeh Ansari

    New findings in Alzheimer’s disease support longstanding notions of what doctors have preached for years. The studies look at associations, not causes, but they further scientists’ pursuit of preventing the fatal brain disease.

    It’s no secret that healthy diet high in omega-3 fatty acids and rich in vitamins found in fruits and vegetables is good for your overall health and longevity.

    In a study released this week in the journal Neurology, scientists associate these fish-rich diets and foods with high levels of vitamins B, C, D, and E nutrients with increased cognitive performance and decreased risk of Alzheimer’s disease, or “brain shrinkage.”

    People who consume diets high in trans fats, primarily found in fast foods, fried and frozen foods, were more likely to have brain shrinkage and lower scores on the thinking and memory tests than people with diets low in trans fats, the study found.

    This is the first study using nutrient biomarkers in the blood to look at the effect of diet on memory, thinking skills and brain volume, researchers said. Similar diet studies in the past primarily depended on participants’ memory recall and questionnaires.

    “These results need to be confirmed, but obviously it is very exciting to think that people could potentially stop their brains from shrinking and keep them sharp by adjusting their diet,” said study author Gene Bowman, assistant professor of neurology at the Oregon Health and Science University, in a news release from the American Academy of Neurology.

    Researchers say diet is just one of many factors that must be taken into consideration when talking about memory loss. People have different genetic tendencies for disease risk, therefore more multigenerational and multicultural studies need to be conducted.

    “The assumption is that when you lead a healthy lifestyle, which includes proper nutrition, exercise, and social engagement, you’re maximizing your chance of reduced cardiovascular risk factors, which then maximize your opportunities for delaying Alzheimer’s or dementia,” said Maria Carrillo, senior director of medical and scientific relations at the Alzheimer’s Association.

    “Whether that translates into delaying Alzheimer’s, we actually don’t know,” added Carrillo.

    In a different study, supported by the National Institutes of Health, new research links “silent strokes,” or small spots of dead brain cells, to memory loss in the elderly.

    The study found silent strokes in roughly one out of four older adults. The affected adults scored somewhat worse on memory tests than those without silent strokes.

    Researchers found this was true whether or not people had a small hippocampus, which is the main memory center of the brain.

    “Given that conditions like Alzheimer’s disease are defined mainly by memory problems, our results may lead to further insight into what causes symptoms and the development of new interventions for prevention,” study author Adam M. Brickman said in a statement. Brickman works for the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain at Columbia University Medical Center in New York.

    Alzheimer’s disease is the sixth leading cause of death in the United States, according to the Alzheimer’s Association. It is the only cause of death in the top 10 in America without a way to prevent, cure, or even slow its progression.

    “Since silent strokes and the volume of the hippocampus appeared to be associated with memory loss separately in our study, our results also support stroke prevention as a means for staving off memory problems,” said Brickman.

    The study will be published in the medical journal of the American Academy of Neurology next week.

  • Cravings: Why They Strike, How to Curb Them

    This excellent article by Katherine Kam was originally posted on WebMD. It’s reproduced here in its entirety. A big thanks to Ms. Kam and to WebMD for letting us share this with you.

    Almost everyone has hankered after potato chips, ice cream, chocolate, or another beckoning treat. But why? And what do you do when a craving calls your name? Is it OK to give in once in a while? What if your cravings start to run amok and demand satisfaction every day?

    Food Cravings From the Inside Out

    Cornell professor Brian Wansink, PhD, makes it his business to understand food cravings. He’s studied a woman who loved to cuddle up with her favorite snack: a bowl of popcorn mixed with M&Ms. He knows why hearty men crave steaks and pizza, while women usually go for candy or cookies.

    Insight into cravings is important because our environment is loaded with sensory cues that can prompt us to overeat, Wansink says. He directs Cornell University’s Food and Brand Lab, which studies consumers’ relationships with food. (The lab’s motto: “We uncover eating traps and change them.”) He also wrote the book, Mindless Eating: Why We Eat More Than We Think.

    Visual cues — such as seeing enticing foods — are the most frequent environmental triggers. Smells are potent, too. For instance, “You walk by a Cinnabon,” Wansink says, and the rich, sweet aroma can automatically trip a strong desire for the cinnamon rolls.

    Don’t Blame Nutrition

    One popular myth holds that people crave certain foods to fill a nutritional deficiency.

    “The naive view has always been that cravings represent wisdom of the body,” says Marcia Pelchat, PhD, a food researcher at the Monell Chemical Senses Center in Philadelphia.

    But it’s not so. Some of her work has shown that people have cravings even when they’re fed a diet that’s completely adequate in calories and nutrients.

    “People will often say things, like, ‘Gee, I’m craving potato chips. I’d better eat some because I must need the salt,’” Pelchat says. “But really, how many of us — aside from runners in hot weather — are deficient in salt? And then how do you explain cravings for sweets in terms of deficiency?”

    We feel virtuous blaming cravings on nutritional needs, Pelchat says. But “we don’t have such great wisdom of the body,” she says. “Unfortunately, humans rely less on instincts and more on culture to determine what they eat — or on individual experience.” (In her city, for example, a lot of men crave Philly cheese steaks.)

    Culture, Sex, and Cravings

    Wansink agrees that culture and gender play a big role in cravings. In his research, men were more likely to crave pizza, pasta, and soup over cakes and cookies. Why? Besides being tasty and filling, such hot, savory foods reminded them of attention from their mothers or wives.

    In contrast, women liked these foods well enough, but associated them with work, including preparation and cleanup. So instead, women tended to crave hassle-free snack foods, such as candy, cookies, ice cream, and chocolate.

    What about that woman who liked popcorn mixed with M&M’s? Not only was the snack easy to prepare, but it made her feel “cozy and safe,” Wansink says. She and her husband had made it as a “secret snack” when they were dating in college; hence, the positive association turned it into her favorite craving.

    Almost everyone has hankered after potato chips, ice cream, chocolate, or another beckoning treat. But why? And what do you do when a craving calls your name?

    Is it OK to give in once in a while? What if your cravings start to run amok and demand satisfaction every day?

    Good Mood, Bad Mood

    Certain emotions, including stress, sadness, and boredom, can promote cravings, Pelchat says. “That’s another very strong correlate of cravings. A bad mood can become a conditioned cue for eating. Just like walking by the donut shop, being in a bad mood becomes a cue that elicits going over to the refrigerator.”

    Those negative moods get all the press, but Wansink suggests that happy moods might be even more likely to cause cravings. In his survey of about 1,000 Americans, 86% reported that they craved comfort foods when they were happy, and 74% had cravings when they wanted to celebrate or reward themselves. In contrast, 52% had cravings when they were bored and 39% when they were sad or lonely.

    The happy eaters craved food to maintain their upbeat mood, he explains: “I want to do something to extend my happy feeling or my happy experience.” Furthermore, they tended to prefer “more meal-like, healthier foods,” he says. In contrast, people in sad moods were much more likely to seek out ice cream, cookies, or potato chips.

    You also learn to crave certain foods in certain situations. “If you have a cookie every day after school, just walking into the house cues you to have a cookie,” Pelchat says. “If you don’t get that cookie right away, your mind obsesses about it and turns it into a craving.”

    Taming Your Cravings

    So you want to put your cravings back in their place. What should you do?

    Don’t waste your time on bizarre methods. They don’t work for most people. For example, some models deal with cravings for sweets by taking one bite from a candy bar and spitting it out, or carrying a candy wrapper to sniff, Wansink writes in his book.

    Here are some expert tips to try instead:

    Eat the Food You Crave Less Often

    You may have heard that having a little bit of the food you crave is a good way to break the craving. Maybe not.

    “We used to think that eating a small amount of those foods would extinguish a craving. For a long time, we thought that that was the way to deal with cravings, and it just doesn’t seem to work for most people,” Wansink says.

    Rather than quitting the craving, continually eating the food may just strengthen the habit. “The more you eat sweets, the more you reinforce the cravings for sweets,” Pelchat says.

    So should you go cold turkey? No, Wansink says. Feeling deprived of a favorite food often backfires and you end up eating too much. “You can indulge in it, but just do it less frequently,” he says.

    Use Portion Control

    “Allow yourself to have a food, but do it in a portion-controlled way,” Pelchat says. For example, don’t keep tempting foods at home, because it’s too easy to wolf down excessive amounts. Instead, go out for one scoop of ice cream or one slice of pizza.

    Also, know yourself. Portion control doesn’t work for everyone, especially if tempting foods are on hand. Some people can count out and eat only 15 smoked almonds; others routinely barrel their way to the bottom of the can.

    “If you can’t manage portion control, then you want to weaken the link between cues in the environment and eating that food,” Pelchat says. Hide the food in the back of a cupboard; don’t keep it on a kitchen counter or in plain sight. “If you resist, you weaken the link between cues and mindless eating,” she says.

    Substitute a Healthier Food

    “There’s a very fine line between eating an unhealthy food and a healthy food in terms of how it satisfies cravings,” Wansink says. “You may be dying for that chocolate sundae or whatever, but eating something that’s healthier will eliminate that craving almost as effectively.”

    For instance, eating apple slices with peanut butter might satisfy your craving as much as if you really did splurge on ice cream, he says. The sense of satisfaction might not happen immediately or even five minutes later, but it will kick in 15 to 20 minutes later, he says.

    Just make sure to eat an amount equal to the volume of the craved food. Otherwise, “you’re still going to be hungry,” Wansink says — and your craving will still be there, waiting for you to give in.

    Distract Yourself With an Activity Unrelated to Food

    “Substitute something else until the craving goes away. It could be in the form of taking a walk or doing pushups or calling a friend,” Wansink says. Cravings are fleeting, he says. They’ll diminish or go away within an hour, if not sooner.

    Don’t wait out a craving passively. An activity that’s “somewhat absorbing” will help you to resist, Pelchat says. “Even counting to 10 does help,” she adds. “People are less likely to eat the craved food. It gives them more control over it.

    Have a Plan to Combat Chronic Cravings

    “The most dangerous cravings are the ones that are chronic. Those are going to be the most difficult ones to deal with,” Wansink says.

    Let’s say that on most days, around 3 p.m., you crave a sweet or salty food — jelly donuts or a big bag of cheese puffs. “In those cases, it can’t be a piecemeal, day-by-day strategy,” he says. That’s a set-up for failure.

    It’s better to have a steadfast plan. Make sure to have sugarless gum on hand, ready to pop into your mouth when the craving strikes. Or make it routine to take a walk at that time. “Habitually, you replace that craving,” Wansink says.

  • Green Tea Extract and Weight Loss

    Green Tea Extract and Weight Loss

    A fascinating new study adds to the growing body of literature showing that green tea can impact weight gain and be an important tool in the fight against obesity.

    In the current study, published in Obesity, obese mice that were fed a weight-gaining diet put on significantly less weight when they were supplemented with green tea extract.

    The mice were allowed to eat as much as they wanted anytime they wanted. Their diet consisted of unlimited amounts of the mice equivalent of McDonald’s, with everything on the menu supersized.

    In addition to this Vegas buffet of mice chow, one group of mice were fed EGCG (epigallocatechin-3-gallate), the polyphenol in green tea that has been found to have the most profound effect on metabolism and weight. The other group was not.

    The group getting the EGCG supplement gained weight at about 45% the rate of the non-supplemented mice.

    “There’s no difference in the amount of food the mice are eating”, Lambert told Science Daily. “The mice are essentially eating a milkshake, except one group is eating a milkshake with green tea”.

    Lambert estimates that a person would need to drink ten cups of green tea each day to match the amount of EGCG used in the study. But remember, most estimates of how much EGCG are in one cup of brewed tea range from 5-40 mg, so at that rate, sure, ten cups would give you anywhere from 50 to 400 mg of EGCG.

    One single capsule of EGCG (green tea extract (EGCG) provides 250 mg, the amount you’d get from 10 cups providing 25 mg each, or approximately 6 cups providing 40 each.

    The researchers in this study also noted that fecal fat excretion was 30% higher in the EGCG mice. The belief is that EGCG somehow reduces production in the pancreas of the fat-digesting enzyme lipase so that some of the fat you eat isn’t actually digested. (This is exactly how the weight loss pill ALLI works).

    “There seems to be two prongs to this”, said Lambert. “First, EGCG reduces the ability to absorb fat and, second, it enhances the ability to use fat”.

    The excellent thing about drinking green tea and taking green tea supplements is that even if they don’t help you lose weight—and there’s no reason they shouldn’t!—they do a million other good things for you.

    Green tea (and green tea extract, EGCG) have been shown to have preventive effects in obesity, insulin resistance, and hypertension. Green tea polyphenols like EGCG have been shown to have a role in cancer prevention. And green tea itself contains a nice relaxing compound called Theanine which is actually used as a drug in Japan for anxiety and which is available as a supplement.

    There aren’t too many supplements you can take that can positively impact your weight and have as “side effects” anti-inflammatory, anti-oxidant, anti-insulin resistance, anti-hypertension and anti-cancer activity!

  • Protein and Weight Gain

    A new study in JAMA adds to the growing body of literature showing that protein is critical for managing weight.  In this study, the researchers wanted to see what effect (if any) different amounts of protein in the diet would have on weight gain.

    They started with the basic premise that anyone who overeats—however “overeating” may be defined for each person— is going to gain weight. OK, so far, so good. If the researchers were to overfeed a bunch of subjects by, say, 1000 calories a day for a couple of weeks, they could reasonably expect all of them to gain some weight.

    The question for the researchers, however, was this: does it matter what we feed them? Specifically, would the amount of protein in the “over-eating” diet make any difference when it comes to weigh-in time?

    So they took 25 healthy men and women and put them on a “weight-stabilizing” diet for 13-25 days. After that, the folks were divided into three groups. For the next eight weeks, each person ate a daily diet containing 1000 more calories than that individual needed to maintain his or her weight, regardless of which group they were in.

    • Group One ate a diet consisting of 5% protein (low protein diet)
    • Group Two’s diet contained 15% protein (average protein diet)
    • Group Three’s diet was 25% protein (high-protein diet)

    The researchers weren’t just interested in whether protein in the diet affected weight gain. They were also interested in whether or not it affected body composition  researchers were also interested in body composition. They wanted to know how much of the expected weight gain was fat and how much was muscle, and whether those results were impacted by the amount of protein eaten.

    Interestingly…

    • The low-protein group gained the least amount of weight (approximately 7 pounds)
    • The “normal” protein group gained 13.3 pounds
    • The “high-protein” group gained more than twice as much as the low-protein group, weighing in at an average of 14.4 pounds heavier than when they started

    However.

    When the researchers looked at body composition, it was a whole different story:

    • The low-protein group lost about 1.5 pounds of muscle (or lean body mass)
    • The medium (“normal”) protein group gained 6.3 pounds of lean body mass.
    • The high-protein group gained about 7 pounds of muscle!

    “The low-protein group stored a higher percentage of calories as fat than the other groups”, lead researcher George Bray told WebMD.  “The low-protein diet was clearly not good in terms of preserving lean body mass”.

    Another great “side-effect” of the higher protein intakes: a boost in metabolism. The researchers found that resting energy expenditure (the amount of calories you burn when laying around on the couch) actually went up for the people in both the “normal” (15%) and “high” (25%) protein groups. For the low-protein group? Not so much. (Not at all, actually.) This is hardly surprising, since the more muscle you have the more calories you burn– one of the many reasons to use weight training for fat loss.

    Years ago, the distinguished past-president of the American Society of Bariatric Physicians Mary Vernon, MD, told me that in her own clinical practice she saw case after case of overweight people putting on muscle even without exercising, just by eating more protein. Obviously, that was an anecdotal story albeit from a very reliable source, but this study seems to confirm the likelihood of that happening.

    This study demonstrates the importance of protein in putting on muscle (and, of course, in preserving lean body mass when losing weight). Remember, most people in America are on the low-end of protein consumption, not the high end!

    People who eat according to my Unleash Your Thin weight loss meal plans usually lose weight while preserving lean body mass because they are eating a large portion of protein at every meal.

  • Top 10 Fitness and Nutrition Tips for…1998?

    Recently I came across some of my old columns from the 90’s and decided to sample some of them to see what I was thinking back a decade or so ago. I was especially curious to see in what areas my thinking had evolved. I fully expected to slap my hand to my forehead in mock embarrassment, the way we all do when grandma brings out those embarrassing home videos of us when we were 7.

    But I’m sharing this one with you because I think you’ll get a kick out of it. Back then, I was writing in much more polite and moderate tones (still hoping to convince the “establishment” of the error of their ways and not realizing that they were pretty much unmovable when you questioned their treasured notions about weight loss, nutrition and exercise).

    Hard to imagine, but much of what I said in this column was considered very controversial at the time. I hope that when I look back on the columns I’ve written in the past year, especially those considered so controversial now—my enthusiasm for large doses of supplemental vitamin D, my rants against the insanity of using cholesterol as a marker for heart disease—will stand the test of time as well as what you’re about to read below.

    Best of all would be if in a decade or two, what I’ve been saying would be considered so obvious and uncontested that no one can remember that it was ever controversial!

    So here’s my column from 12 years ago. As always, let me know what you think!

    Jonny Bowden’s Top 10 Fitness and Nutrition Tips for 1998

    1. Forget the fat burning zone: When trying to burn calories, work as hard as you can for as long as you can so long as you don’t cause injury or burnout. The idea that you will only lose fat if you work in some magic “zone” is simply untrue. If you enjoy working at the lower intensities, make sure you compensate by going longer.
    2. Do Interval Training: One way to add variety, challenge, extra intensity and additional calorie burn to your regular routine is  to insert high intensity intervals into your cardiovascular workout. You can do this at any level of fitness training. For example, if you’re walking, speed up the pace to as fast as you can for anywhere from 30 seconds to 2 minutes; then return to your normal cruising pace. You can easily insert high intensity intervals into stair climbing, treadmill and stationary bicycling routines as well.
    3. Consider Circuit Training: In this style of training, you go from exercise to exercise (“a circuit”) with little rest in between, giving yourself a challenging full body workout that makes the most of limited exercise time; one body part recovers while you work another. For maximum challenge you can also intersperse aerobic intervals of three minutes- such as jumping rope-  after every two or three weight training exercises.
    4. Lift Weights: Forget your fears of becoming too bulky. It rarely happens with women, and only in genetically gifted specimens who train for a living. Weight training gives your muscles tone and shape and is your best ally in fat-burning. Here’s why: most of your calories are burned in the power centers of the muscle cells, known as mitochondria. The more muscle you have, the more of these fat burning powerplants you have working for you.
    5. Throw Out Your Margarine: Probably one of the biggest mistakes the health establishment ever made was the promotion of this ridiculously unhealthy butter substitute, which is loaded with something called trans-fatty acids. Many nutritionists now consider trans-fatty acids the most health-destructive of all the fats. Trans-fatty acids can also be found in high amounts in shortening, cookies, crackers, candies french fries, pastries and potato chips.
    6. Don’t Trust The Media: When it comes to honest, fair reporting of nutritional information, caveat emptor. Mainstream doctors and nutritionists, and the reporters who get their information from them, are notoriously conservative, and parrot exactly what they’ve been told, often not looking much further than the surface. The chances of getting a fair report, for instance,  on any eating plan that suggests you consume less than 60% carbohydrates is equal to that of the proverbial snowball in you-know-where.
    7. Eat your Eggs (if you like them): The evidence is now pretty incontestable that dietary cholesterol has a trivial effect on serum cholesterol. So don’t fall for the ridiculous claim that because a product has “O% cholesterol” it’s therefore a healthy product. And by the way, a great deal of valuable nutrients are found in the yolk, including lecithin.
    8. Don’t Be A Fat-Phobic: The wholesale avoidance of fat that has become the mantra of the diet industry is not only misguided, it’s downright unhealthy. Without fat, we can’t absorb the important fat-soluble vitamins such as vitamin E. We eat far too many fats from vegetable oils and not nearly enough from fish, for example, and this unhealthy imbalance is thought to be a major contributor to a host of common health problems. Monounsaturated fats like those found in olives, olive oil, almonds, hazelnuts and avocados are very stable fats that have many benefits.
    9. Eat More Like A Caveman: There are many lessons to be learned from Paleolithic Nutrition, as readers of this column know. Hunter-gatherers existed on wild game, fish, shellfish, plus a seasonal variety of wild vegetables, fruits, seeds and nuts. The pre-agricultural diets rarely contained concentrated carbohydrate sources such as sugar, flour, rice and pasta. Try as best you can to eliminate processed and packaged foods from the daily diet, and replace them with fruit, vegetables, meat and fish.
    10. Love Yourself More: If there’s any one thing I’ve learned in ten years of coaching it’s that Life and Fitness aren’t two separate things. If you wait to feel good about yourself till you lose some magic amount of weight you think you need to lose, you’re in for some tough times ahead. Enjoy the journey. Aim for the stars, but enjoy the ride. Self-acceptance isn’t dependent on a perfect dress size, and a perfect dress size doesn’t guarantee self-love.

    I can’t end 1998 without letting all of you know what a privilege it’s been being able to interact with you throughout the year, through the chats, the Shape Up Programs, the message boards and my columns. I thank you all for trusting and believing in me, for your wonderful letters and e-mails, and for being willing to take risks; I thank you for being willing to participate with me and with each other; and most of all, I acknowledge and appreciate you for being willing push past the invisible ceilings of self-limitation by being just as big as you can be… and then some.

    And I look forward to doing it all together again in 1999.

    Merry Fitness, Happy Holidays, and much, much love.

  • Vitamin D Delays Progression of Diabetes

    Guest article by John Cannell, MD, president of the Vitamin D Council

    Diabetes mellitus type 2, or adult-onset diabetes, is epidemic, according to the CDC. It is a disease of high blood sugar with insulin resistance or insulin deficiency. Insulin resistance is what it sounds like. The cells are resistant to the action of insulin, and insulin resistance often leads to adult diabetes. However, adult diabetes is no longer a useful term. Since the sun-scare, adult-onset diabetes is often diagnosed in children. Frequently, but not always, it is a disease of the obese. Exercise and diet helps.

    • In 2003, about 130 million people in the world had type 2 diabetes.
    • In the United States, 8% of the population has type 2 diabetes.
    • The disease doubled between 1990 and 2005 thanks to sun-scare, soda, and obesity.

    How many times have you heard that we need randomized controlled trials before we start taking vitamin D? Well, they are coming fast and furious. This August, researchers at Tufts University released a double blind randomized controlled trial that showed  2,000 IU/day of vitamin D3 had a major effect on insulin resistance.

    I liked what the authors said, “These results suggested that vitamin D may have a role in delaying the progression to clinical diabetes in adults at high risk of type 2 diabetes. …”

    Two thousand IUs per day for 4 months only increased 25(OH)D levels from  24 to 30 ng/ml.

    Why such a small increase in 25(OH)D?

    The average subject weighed 223 pounds, that’s why.

    This is good proof that the FNB was wrong when they said 20 ng/ml is as good as it gets.

    Remember the recent Food and Nutrition Board (FNB) said that levels of 20 ng/ml are just fine, do not expect any improvements with levels higher than 20 ng/ml.

    Keep in mind the NIH, especially the Office of Dietary Supplements, are against, not for, dietary supplements. They are especially sensitive to anyone implying the FNB study they helped fund is working against what they set to accomplish: to better the health and lives of individuals.

    The authors failed to write even a sentence about dose, and I assume it is because Tufts University wants some more NIH grants.

    If going from 24 to 30 ng/ml showed such an improvement in insulin sensitivity, the obvious question is what would going from 24 to 40 ng/ml do?

    I don’t think the authors wanted to embarrass the FNB anymore than their findings already did.

    Dr. Jonny Comments:

    Dr. Conell is pointing out something we’ve been saying for years: “adequate” nutrition is not the same as “optimal” nutrition. All the hooplah from the anti-supplement forces claiming that we need “only” 600 IUs a day of vitamin D is based on a very narrow reading of the research that speaks only and specifically about bone health and not the 100 other conditions that vitamin D can impact. Here’s one small example of the many ways vitamin D has a significant benefit that goes way beyond strong bones, and to get that benefit you need a heck of a lot more than the paultry 600 IUs the FNB solemnly declared was “all we need”.

    The columnist and commentator George Will once said something very amusing but very true. He said he had three major rules (to which I am going to add another). Will’s three “rules for life” were:

    1. Don’t play poker with a man named Slim

    2. Don’t take financial advice from a guy who’s yelling

    3. Don’t buy a Rolex from a man who’s running.

    To which I’d add:

    4. Don’t take your nutritional advice from the Government. Really.

  • New Study: Curcumin Suppresses Cancer Growth

    ScienceDaily (Sep. 13, 2011) —

    Curcumin, the main component in the spice turmeric used in curry, suppresses a cell signaling pathway that drives the growth of head and neck cancer, according to a pilot study using human saliva by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

    The inhibition of the cell signaling pathway that drives the growth of these cancers also reduced a number of pro-inflammatory cytokines, or signaling molecules, in the saliva that promote cancer growth, said Dr. Marilene Wang, a professor of head and neck surgery, senior author of the study and a Jonsson Cancer Center researcher.

    “This study shows that curcumin can work in the mouths of patients with head and neck malignancies and reduce activities that promote cancer growth,” Wang said. “And it not only affected the cancer by inhibiting a critical cell signaling pathway, it also affected the saliva itself by reducing pro-inflammatory cytokines within the saliva.”

    The study appears Sept. 15 in Clinical Cancer Research, a peer-reviewed journal of the American Association of Cancer Research.

    Turmeric is a naturally occurring spice widely used in South Asian and Middle Eastern cooking and has long been known to have medicinal properties, attributed to its anti-inflammatory effects. Previous studies have shown it can suppress the growth of certain cancers. In India, women for years have been using turmeric as an anti-aging agent rubbed into their skin, to treat cramps during menstruation and as a poultice on the skin to promote wound healing.

    A 2005 study by Wang and her team first showed that curcumin suppressed the growth of head and neck cancer, first in cells and then in mouse models. In the animal studies, the curcumin was applied directly onto the tumors in paste form. In a 2010 study, also done in cells and in mouse models, the research team found that the curcumin suppressed head and neck cancer growth by regulating cell cycling, said scientist Eri Srivatsan, an adjunct professor of surgery, article author and a Jonsson Cancer Center researcher who, along with Wang, has been studying curcumin and its anti-cancer properties for seven years.

    The curcumin binds to and prevents an enzyme known as IKK, an inhibitor of kappa β kinase, from activating a transcription factor called nuclear factor kappa β (NFκβ), which promotes cancer growth.

    In this study, 21 patients with head and neck cancers gave samples of their saliva before and after chewing two curcumin tablets totaling 1,000 milligrams. One hour later, another sample of saliva was taken and proteins were extracted and IKKβ kinase activity measured. Thirteen subjects with tooth decay and five healthy subjects were used as controls, Wang said.

    Eating the curcumin, Wang said, put it in contact not just with the cancer but also with the saliva, and the study found it reduced the level of cancer enhancing cytokines.

    An independent lab in Maryland was sent blind samples and confirmed the results — the pro-inflammatory cytokines in the saliva that help feed the cancer were reduced in the patients that had chewed the curcumin and the cell signaling pathway driving cancer growth was inhibited, Wang said.

    “The curcumin had a significant inhibitory effect, blocking two different drivers of head and neck cancer growth,” Wang said. “We believe curcumin could be combined with other treatments such as chemotherapy and radiation to treat head and neck cancer. It also could perhaps be given to patients at high risk for developing head and neck cancers — smokers, those who chew tobacco and people with the HPV virus — as well as to patients with previous oral cancers to fight recurrence.”

    The curcumin was well tolerated by the patients and resulted in no toxic effects. The biggest problem was their mouths and teeth turned bright yellow.

    “Curcumin inhibited IKKβ kinase activity in the saliva of head and neck cancer patients and this inhibition correlated with reduced expression of a number of cytokines,” the study states. “IKKβ kinase could be a useful biomarker for detecting the effects of curcumin in head and neck cancer.”

    To be effective in fighting cancer, the curcumin must be used in supplement form. Although turmeric is used in cooking, the amount of curcumin needed to produce a clinical response is much larger. Expecting a positive effect through eating foods spiced with turmeric is not realistic, Wang said.

    The next step for Wang and her team is to treat patients with curcumin for longer periods of time to see if the inhibitory effects can be increased. They plan to treat cancer patients scheduled for surgery for a few weeks prior to their procedure. They’ll take a biopsy before the curcumin is started and then at the time of surgery and analyze the tissue to look for differences.

    “There’s potential here for the development of curcumin as an adjuvant treatment for cancer,” Wang said. “It’s not toxic, well tolerated, cheap and easily obtained in any health food store. While this is a promising pilot study, it’s important to expand our work to more patients to confirm our findings.”

    Dr. Jonny Comments:
    Curcumin is fast becoming one of the hot topics in nutritional supplementation, along with asataxthin, resveratrol, vitamin K and vitamin D. This is just one of a number of studies showing curcumin’s positive effect on cancer tumors. Curcumin is also one of the most helpful compounds for the liver, and is highly anti-inflammatory as well. It’s also wonderful for pain, particularly pain from inflammation (i.e. arthritis, joint pain, etc.)

    I think we’ll see more and more studies like this showing the enormous benefits of this supplement. Curcumin is the main reason i gave turmeric– which is the spice in which curcumin is found– a “Star” in my book, “The 150 Healthiest Foods on Earth“. I use it on vegetables, eggs, and all sorts of other dishes. And I  take the supplement on a daily basis.

  • Featured Recipe: Savory Slow Cooker Tender Turkey Drumsticks

    Featured Recipe: Savory Slow Cooker Tender Turkey Drumsticks

    The following recipe is from “The Healthiest Slow-Cooker Recipes on Earth”, by myself and Jeannette Bessinger, available on Amazon.com – order here.

    Savory Slow Cooker Tender Turkey Drumsticks

    Turkey is a great, healthy source of protein (over 20 grams per serving) and turkey drumsticks are always a favorite. And you don’t have to wait till the holidays to enjoy them. This recipe is super easy, super fast, and when you use the slow cooker it cooks to a delicious tenderness in its own juices –no added fat calories. Yum. Seriously.

    Perfectly healthy fat replaces the conventional gravy or commercial cream of mushroom soup that generally smothers a dish like this. (Note: a can of commercial cream of mushroom soup has an astonishing 1995 mg of sodium. Need I say more?)

    Onions are a rich source of sulfur, so good for the skin, not to mention that they are one of the richest sources of a flavonoid called quercetin which is one of the most anti-inflammatory plant compounds on the planet. (Quercetin has also been shown to have significant anti-cancer properties.) Something to remember: Turkeys are frequently raised under horrific factory farmed conditions, so if possible, get the free-range variety. They’re almost always better for you anyway.

    Ingredients

    •  1 tablespoon olive oil
    • 3 turkey drumsticks
    • Sprinkles salt and cracked black pepper, to taste
    • 1 large Vidalia onion, chopped
    • 3 large carrots, peeled and sliced into thin coins
    • 2 large cloves garlic, minced
    • ½ teaspoon dried sage, crumbled
    • 2 tablespoons fresh parsley, chopped
    • 1 tablespoon fresh thyme, chopped (or use 1 teaspoon dried)
    • 1 lemon, halved

    Directions

    1. Oil the bottom of the slow cooker and the drumsticks with olive oil.
    2. Sprinkle liberally with salt and pepper, to taste.
    3. Place onions and carrots in the bottom of the cooker and top with prepared drumsticks.
    4. In a small bowl, mix garlic, sage, parsley and thyme together and sprinkle evenly over the drumsticks.
    5. Gently squeeze the lemon halves to release their juices into the vegetables and nestle them in at the bottom of the pot.
    6. Cook on low for 8-10 hours, or high for 4-5 hours or until meat is cooked through and meat and veggies are very tender.

    Yield: 4 servings

     

  • The Single Most Cost-Effective Medical Intervention!

    The Single Most Cost-Effective Medical Intervention!

    More than half of global mortality rates can be accounted for by six diseases:

    • Cardiovascular disease
    • cancer
    • respiratory infections
    • respiratory diseases
    • tuberculosis
    • diabetes

    What do all six have in common?

    They are all vitamin-D sensitive.

    And it’s not just those six diseases…

    • Alzheimer’s
    • meningitis
    • Parkinson’s
    • maternal sepsis
    • pre-eclampsia
    • MS
    • deaths from falls

    …account for an additional 2-3% of global mortality and each of these is also vitamin D sensitive.

    William B. Grant, PhD, is the director of the Sunlight, Nutrition and Health Research Center (gotta love that name).  The Center is devoted to research, education and advocacy relating to the prevention of chronic disease through changes in diet and lifestyle. Recently, Dr. Grant undertook a statistical analysis of global mortality rates and their relationship to vitamin D status in six regions in the world. His study was published in the European Journal of Clinical Nutrition.

    Here’s what he found.

    Doubling vitamin D levels from approximately 54 nmol/L to 110 nmol/l  would essentially reduce global mortality from vitamin D sensitive diseases by a whopping 20%. Doubling vitamin D levels would result in 7.6% fewer deaths among African females and 17.3% fewer deaths among European females. (Males would enjoy similar reductions, just roughly half a percentage lower on average than females.)

    The total increase in life expectancy from doubling vitamin D levels averaged out to two additional years across all six regions studied.

    Not bad for a supplement that is one of the cheapest and safest on earth.

    The actual levels we’re discussing matter a lot here; if someone is already at an optimal level of vitamin D, doubling it probably won’t have much effect. But most people are woefully under the optimal levels.

    Vitamin D Levels (25-hydroxyvitamin D)

    Deficient

    Insufficient

    Optimal

    Cancer therapy

    Excess

    <25ng/ml

    <35ng/ml

    50-65ng/ml

    65-90ng/ml

    >100ng/ml

    <20nmol/L

    <40-80nmol/L

    80-120nmol/L

    120-160nmol/L

    >200nmol/L

     

    Note: The most common measurement standard for vitamin D in the blood used in the United States is ng/ml (nanograms per milliliter); the other measurement—nmol/L (nanomoles per liter) is often used in Europe.

    “Increasing serum 25 (OH) D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake…” commented Dr. Grant.

    Indeed. Less than optimal levels of vitamin D have been shown to be strongly associated with a host of conditions from an inability to lose weight, to diabetes, to poor physical performance in older adults, to mood disorders, to MS and to cancer.

    Vitamin D belongs on the short list of essential supplements that I think would benefit just about anyone. I recommend 2,000 IUs a day (although I take considerably more). The current recommendations (RDAs) for vitamin D are 600 IUs for anyone from 1-70 years of age.

    To be blunt, those recommendations are just stupid.

    Get your doctor to do a 25(OH) vitamin D test- the only kind that means anything. Supplement till you get your level to at least 50 (some experts like it higher) and then keep it there.

    To quote Greg Plotnikoff, MD, Medical Director, Penny George Institute for Health and Healing, Abbott Northwestern Hospital in Minneapolis:

    Because vitamin D is so cheap and so clearly reduces all-cause mortality, I can say this with great certainty: Vitamin D represents the single most cost-effective medical intervention in the United States.