B vitamins and colorectal cancer
Increased intake of vitamin B6 from dietary and supplements may reduce the risk of colorectal cancer by over 20 per cent, suggests a large Scottish study.
Almost 5,000 people took part in the study, which reported a dose-dependent link between intake of the vitamin and the risk of colorectal cancer, report the researchers in the journal Cancer Epidemiology Biomarkers & Prevention.
The study, by researchers from the University of Edinburgh, Western General Hospital (Edinburgh) and the University of Aberdeen, adds to an ever growing body of science supporting the potential colorectal benefits of higher intake of the
B vitamins.
After adjusting the results for potentially confounding factors such as age, sex, location of the tumour, folate status, and certain genotypes, lead author Evropi Theodoratou reported: "Moderately strong inverse and dose-dependent associations in the whole sample were found between CRC risk and the intake of dietary and total vitamin B6."
Translated: No matter how you slice and dice the data, vitamin B6 seems to play an important role in preventing colorectal cancer.
Furthermore, a meta-analysis of published studies supported these results, wrote the researchers. High vitamin B6 intakes were reported to reduce the risk of colorectal cancer by 19 per cent. The protective effect was found to be higher among 55-year-old individuals (1,001 cases compared to 1,010 controls), they added.
In earlier research in the Journal of Nutrition (Vol. 137, pp. 2701-2708), Tufts researchers stated that moderate deficiency of folate, B2, B6 and B12 together may promote the risk of DNA damage and increase the risk of colorectal cancers.
Mild depletion of all four of these B vitamins seems to promote the risk of tumour formation.
Previously, studies have suggested that folate deficiency alone may promote the risk of colorectal cancer. The new research suggests a more complex interaction.
Bottom line: get all your B's. Especially as we age, B12 absorption is compromised. Vegans and vegetarians are at increased risk for less than optimal B12 deficiencies, despite what you may have read. And as an added bonus, three of these vitamins- B6, B12 and folate- work together to bring down homocysteine, a nasty inflammatory molecule in the blood. High levels of homocysteine are associated with significantly increased risk for heart attack, stroke and Alzheimer's.
Added benefit: Since stress depletes the B vitamins like nobody's business, many people just plain feel better on extra B-complex.
Almost 5,000 people took part in the study, which reported a dose-dependent link between intake of the vitamin and the risk of colorectal cancer, report the researchers in the journal Cancer Epidemiology Biomarkers & Prevention.
The study, by researchers from the University of Edinburgh, Western General Hospital (Edinburgh) and the University of Aberdeen, adds to an ever growing body of science supporting the potential colorectal benefits of higher intake of the
B vitamins.
After adjusting the results for potentially confounding factors such as age, sex, location of the tumour, folate status, and certain genotypes, lead author Evropi Theodoratou reported: "Moderately strong inverse and dose-dependent associations in the whole sample were found between CRC risk and the intake of dietary and total vitamin B6."
Translated: No matter how you slice and dice the data, vitamin B6 seems to play an important role in preventing colorectal cancer.
Furthermore, a meta-analysis of published studies supported these results, wrote the researchers. High vitamin B6 intakes were reported to reduce the risk of colorectal cancer by 19 per cent. The protective effect was found to be higher among 55-year-old individuals (1,001 cases compared to 1,010 controls), they added.
In earlier research in the Journal of Nutrition (Vol. 137, pp. 2701-2708), Tufts researchers stated that moderate deficiency of folate, B2, B6 and B12 together may promote the risk of DNA damage and increase the risk of colorectal cancers.
Mild depletion of all four of these B vitamins seems to promote the risk of tumour formation.
Previously, studies have suggested that folate deficiency alone may promote the risk of colorectal cancer. The new research suggests a more complex interaction.
Bottom line: get all your B's. Especially as we age, B12 absorption is compromised. Vegans and vegetarians are at increased risk for less than optimal B12 deficiencies, despite what you may have read. And as an added bonus, three of these vitamins- B6, B12 and folate- work together to bring down homocysteine, a nasty inflammatory molecule in the blood. High levels of homocysteine are associated with significantly increased risk for heart attack, stroke and Alzheimer's.
Added benefit: Since stress depletes the B vitamins like nobody's business, many people just plain feel better on extra B-complex.
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